Quinolines and derivatives
Apexbio Technology LLC Solanesol 13190-97-1 200mg
Solanesol is a lipophilic terpene alcohol derived from plants in the Solanaceae family characterized by anti-inflammatory neuroprotective and antimicrobial activity In vitro studies indicate solanesol regulates specific signaling pathways implicated in inflammatory responses and neurodegenerative processes possibly through modulation of enzyme activity and intracellular targets Experimental evidence demonstrates solanesol inhibits inflammation-associated enzymes with reported IC50 values typically ranging from low to mid micromolar concentrations depending on cell types and assay conditions This compound is utilized in biochemical research focused on elucidating molecular pathways involved in inflammation-mediated diseases and evaluating therapeutic potential as a neuroprotective agent
Apexbio Technology LLC Methacholine chloride 62-51-1 200mg
Methacholine chloride (CAS 62-51-1) is a synthetic choline ester that selectively activates muscarinic acetylcholine receptors predominantly the M3 subtype on airway smooth muscle cells By stimulating these receptors it induces bronchoconstriction and airway narrowing mimicking pathophysiological responses observed in airway hyperreactivity Methacholine chloride is frequently utilized in research to assess bronchial hyperresponsiveness (BHR) and measure airway hyperreactivity (AHR) in experimental models Clinically it supports the evaluation of asthma-like symptoms in patients with normal baseline pulmonary function
Apexbio Technology LLC GDC-0941 957054-30-7 200mg
GDC-0941 (CAS 957054-30-7) is a selective small-molecule inhibitor of class I phosphoinositide 3-kinase (PI3K) a critical component involved in the PI3K/Akt signaling pathway frequently dysregulated in cancer By competitively binding to the ATP-binding site of PI3K GDC-0941 inhibits generation of the downstream signaling molecule phosphatidylinositol-3 4 5-trisphosphate (PIP3) Exhibiting high selectivity against p110 / (IC50 approx 3 nM) and moderate selectivity for p110 (33 nM) and p110 (75 nM) GDC-0941 has demonstrated antiproliferative activity across diverse tumor cell lines in vitro (e g A2780 PC3 U87MG) and tumor growth inhibition in xenograft cancer models supporting its utility in cancer research
Medchemexpress LLC Temsirolimus | 162635-04-3 | C56H87NO16 | 200MG
Temsirolimus is an inhibitor of mTOR with an IC50 of 1.76 μM. It activates autophagy and prevents deterioration of cardiac function in animal models. This product is an analytical standard intended for research and analytical applications.
- Inhibits mTOR kinase activity
- Activates autophagy
- Prevents deterioration of cardiac function
- Induces apoptosis in primary human lymphoblastic leukemia (ALL) cells
- Delays growth of xenografts
- Improves performance on behavioral tasks in Huntington disease models
Apexbio Technology LLC Emodin 518-82-1 200mg
Emodin (518-82-1) is a small-molecule inhibitor targeting casein kinase 2 (CK2) and the interaction between SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) It is designed to block protein protein interactions and enzyme activity thereby modulating viral entry and kinase-mediated signaling Emodin exerts its biological activity primarily through inhibition of CK2 and disruption of spike ACE2 binding In hepatocellular carcinoma cell models (Hep3B HepG2 Huh7) emodin demonstrates antiproliferative activity with IC50 values of 66 9 M in Hep3B 74 36 M in HepG2 and 101 5 M in Huh7 cells Based on these pharmacological properties emodin holds research potential in cancer inflammation metabolic disorders and viral infection models
Apexbio Technology LLC Oxacillin sodium monohydrate 7240-38-2 200mg
Oxacillin sodium monohydrate (CAS 7240-38-2) is a small-molecule inhibitor within the penicillin class It is designed to inhibit bacterial cell wall biosynthesis thereby disrupting peptidoglycan cross-linking and compromising cellular integrity Oxacillin sodium monohydrate exerts its biological activity primarily through interference with peptidoglycan cross-linking resulting in bacterial lysis In in vitro studies Oxacillin sodium monohydrate demonstrates antimicrobial inhibition with minimum inhibitory concentration (IC50) values typically ranging from approximately 0 1 to several g/mL depending on bacterial strain and assay conditions Based on these pharmacological properties Oxacillin sodium monohydrate holds research potential in antimicrobial susceptibility testing resistance phenotyping and investigations of bacterial resistance mechanisms particularly in gram-positive -lactamase-producing bacteria such as methicillin-resistant staphylococci (MRSA)
Medchemexpress LLC Cephradine monohydrate | 75975-70-1 | 91.0% | 100 MG
Cephradine monohydrate is a broad-spectrum, orally active cephalosporin effective against both gram-positive and gram-negative pathogens. It eradicates most penicillinase-producing organisms resistant to penicillin G, penicillin V, and ampicillin. This compound has been utilized in research concerning genitourinary, gastrointestinal, and respiratory tract infections, as well as infections of the skin and soft tissues. It also blocks solar-ultraviolet induced skin inflammation.
- Active against gram-positive and gram-negative pathogens.
- Effective in eradicating most penicillinase-producing organisms resistant to penicillin G, penicillin V, and ampicillin.
- Used in research of genitourinary, gastrointestinal, and respiratory tract infections.
- Used in research of infections of the skin and soft tissues.
- Blocks solar-ultraviolet induced skin inflammation through direct inhibition of TOPK.
- Targets β-lactam.
Medchemexpress LLC Quizartinib | 950769-58-1 | 99.1% | 200 MG
Quizartinib is an orally active, highly selective, and potent second-generation type II FLT3 tyrosine kinase inhibitor. It inhibits wild-type FLT3 and FLT3-ITD autophosphorylation in MV4-11 cells, with IC50s of 4.2 nM and 1.1 nM respectively. This compound can be linked to the VHL ligand via an optimized linker to form a PROTAC FLT3 degrader, and it induces apoptosis. It is intended for research use only.
- Orally active
- Highly selective and potent type II FLT3 tyrosine kinase inhibitor
- Inhibits wild-type FLT3 and FLT3-ITD autophosphorylation
- Forms PROTAC FLT3 degrader when linked to VHL ligand
- Induces apoptosis
Medchemexpress LLC BML-284 | 853220-52-7 | 100.0% | 350.37 | 200 MG
BML-284 is a potent and cell-permeable Wnt signaling activator. It induces TCF-dependent transcriptional activity with an EC50 of 700 nM.
- Potent Wnt signaling activator
- Cell-permeable
- Induces TCF-dependent transcriptional activity
TARGETMOL CHEMICALS INC ZINC12409120 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. ZINC12409120 (R-4584) is a selective ERK inhibitor.ZINC12409120 inhibits ERK with an IC50 of 5.0 uM.ZINC12409120 inhibits ERK activity by interfering with FGF23(alpha)-Klotho interaction. purity: 99%
Medchemexpress LLC Argatroban (monohydrate) | 141396-28-3 | 99.6% | 5 MG
Argatroban (monohydrate) is a direct, selective thrombin inhibitor used for research purposes. It is effective in preventing thrombus formation and has been studied for its use in creating animal models for thrombolysis.
- Suitable for high-speed applications
- Available in solid form
- Used to inhibit thrombin activity in animals
- Has potential for preventing thrombus formation without aggravating bleeding
- Can enhance reperfusion with TPA in patients with AMI
Medchemexpress LLC CLIP (86-100) | 648881-58-7 | 98.5% | 1674.10 | 5 MG
CLIP (86-100) | 648881-58-7 | 98.5% | 1674.10 | 5 MG
eMolecules Ambeed (4-Formyl-phenyl)-carbamicacidtert-butylester 250mg 521412715 A164452 0 000 144072-30-0 MFCD06245541 221 256 C12H15NO3
Ambeed (4-Formyl-phenyl)-carbamicacidtert-butylester 250mg 521412715 A164452 0 000 144072-30-0 MFCD06245541 221 256 C12H15NO3
Medchemexpress LLC B7-H2/ICOSLG Mouse 50ug
B7-H2/ICOSLG is an important ligand of the T cell receptor ICOS and mediates immune responses It acts as a costimulatory signal promoting T and B cell proliferation cytokine secretion and plasma cell differentiation B7-H2/ICOSLG Protein Mouse (HEK293 His) is the recombinant mouse-derived B7-H2/ICOSLG protein expressed by HEK293 with C-His labeled tag
Medchemexpress LLC Letrozole (Standard) | 112809-51-5 | C17H11N5 | 200 MG
Letrozole (CGS 20267) is a potent, selective, reversible, and orally active non-steroidal inhibitor of aromatase, with an IC50 of 11.5 nM. It selectively inhibits estrogen biosynthesis and can be used for breast cancer research.
- Potent, selective, reversible, and orally active non-steroidal inhibitor of aromatase
- Selectively inhibits estrogen biosynthesis
- Used for breast cancer research
- Exhibits anti-tumor effects in rats
- Inhibits growth of MCF-7 epithelial breast cancer cells